Which toxin is more potent, botulinum toxin or tetanus toxin?

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Potency here means how little toxin is needed to cause deadly effects. Botulinum neurotoxin is extraordinarily potent, acting at nanogram-per-kilogram doses to produce fatal paralysis by blocking acetylcholine release at the neuromuscular junction. Tetanus toxin is also extremely potent but generally requires a somewhat larger amount to reach fatal neurotoxicity, and it causes a different effect by blocking inhibitory signals in the spinal cord, leading to spastic paralysis. Because botulinum toxin achieves lethal effects at much smaller doses, it is considered the more potent toxin.