Most zoonic infections are transmitted from animals to humans but can not be transmitted from human to human.

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Zoonoses originate in animals and are often transmitted to humans through direct contact, contaminated products, or vectors. For many of these infections, initial animal-to-human transmission is the main route, and sustained human-to-human spread is limited or uncommon. Because of that pattern, the statement that most zoonotic infections move from animals to humans and do not spread well between people reflects how these diseases typically behave. There are notable exceptions where human-to-human transmission is possible (certain respiratory viruses, for example), but they are not the majority of zoonotic infections. In practical terms, this is why emphasis in practice is on preventing animal or animal-product exposure and maintaining proper precautions to reduce zoonotic risk.