General paresis is associated with which infection?

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General paresis is a late neurosyphilitic manifestation caused by chronic Treponema pallidum infection. In tertiary syphilis, the brain becomes progressively damaged, leading to psychiatric changes, dementia, and motor symptoms—the classic presentation of general paresis. Therefore, the infection associated with general paresis is syphilis. Tuberculosis, malaria, and leprosy do not produce this neurosyphilitic syndrome.