A granulomatous infection that infects the lungs, intestines and kidneys is

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Granulomatous infections caused by Mycobacterium tuberculosis characteristically form granulomas in the lungs and can spread through the bloodstream to other organs. When TB disseminates, the gastrointestinal tract (often the ileocecal region) and the kidneys can become involved, leading to granulomatous inflammation in both sites. This multi-organ involvement pattern—lung primary with intestinal and renal spread—is a classic feature of tuberculosis.

Histoplasmosis can also affect lungs and disseminate to the GI tract and kidneys, but the specific combination of pulmonary infection with consistent intestinal and renal involvement is most classically associated with TB. Leprosy mainly targets skin and nerves, and sarcoidosis is a noninfectious granulomatous disease that is not defined by infectious spread to these organs.